Beware of cells bearing gifts: cell replacement therapy and arrhythmic risk.

نویسنده

  • Samuel C Dudley
چکیده

Heart failure is a major worldwide health problem that is growing in prevalence despite recent treatment advances. Patients with heart failure ultimately die from either pump failure or cardiac arrhythmia, and there is a link between the degree of contractile dysfunction and arrhythmic risk. Since the 1960s, the definitive therapy for heart failure has been cardiac transplantation, but the limited supply of organs has restricted the impact of this therapy. Starting in the mid-1990s, a series of observations has led to the concept that cells might be used to repair myocardial damage. Subsequently, this therapy has shown promise in ischemic and nonischemic forms of myocardial injury.

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عنوان ژورنال:
  • Circulation research

دوره 97 2  شماره 

صفحات  -

تاریخ انتشار 2005